COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines
نویسندگان
چکیده
منابع مشابه
COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines
Genome-wide pooled shRNA screens enable global identification of the genes essential for cancer cell survival and proliferation and provide a 'functional genetic' map of human cancer to complement genomic studies. Using a lentiviral shRNA library targeting approximately 16,000 human genes and a newly developed scoring approach, we identified essential gene profiles in more than 70 breast, pancr...
متن کاملHuman Cancer Biology Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer
Purpose: Despite continuous improvement of treatment regimes, the mortality rates for non–small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) remain disappointingly high and novel anticancer agents are urgently awaited. ExperimentalDesign:Wecombined thedata fromgenome-wide siRNA screenson tumor cell lethality in a lung and a head and neck cancer cell line. Results: ...
متن کاملExpression of Some Genes Involved in Epigenetic in Breast Cancer Cell Lines: The Effect of Quercetin
Background & Objectives: Breast cancer is one of the most common cancers among women. Incorrect pattern of gene expression involved in epigenetic including APOBEC3B, DNMT-1, and TET-1 can develop breast cancer. Quercetin is a natural flavonoid with antioxidant and anti-cancer properties that have been reported in other studies. To investigate the effect mechanism of quercetin, this study examin...
متن کاملCytotoxic Activity of Juniperus excelsa M. Bieb. Leaves Essential Oil in Breast Cancer Cell Lines
Background and objectives: Juniperus excelsa is a flowering plant that has been applied as traditional medicine for treatment of various disorders such as dysmenorrhea, bronchitis and colds, jaundice and tuberculosis. The aims of the present study were analyzing J. excelsa essential oil and investigation of its cytotoxic activity on three breast cancer cell li...
متن کاملThe Anticancer Effects of Sargassum Boveanum Hydroalcoholic Extract in Human Colorectal Cancer Cell Lines
Background: Colorectal cancer (CRC) is one of the leading causes of death worldwide. Sargassum boveanum is a plant species of brown algae that is widely found in the Persian Gulf. The present study investigated the antioxidant and cytotoxic activity of the hydroalcoholic extract of Sargassum boveanum in colorectal cancer cell lines. Materials and Methods: Sargassum boveanum was collected from t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2011
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkr959